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Irreversible cell-cycle transitions are due to systems-level feedback.

Abstract:
The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle (or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations.
Publication status:
Published

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Publisher copy:
10.1038/ncb0707-724

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Nature cell biology More from this journal
Volume:
9
Issue:
7
Pages:
724-728
Publication date:
2007-07-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Language:
English
Keywords:
Pubs id:
pubs:100370
UUID:
uuid:21cdcef4-31ab-4637-afc7-771fdd4607f0
Local pid:
pubs:100370
Source identifiers:
100370
Deposit date:
2012-12-19

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