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Thesis

Single molecule studies of a voltage-gated potassium channel

Abstract:

This thesis aims to study the activation and deactivation mechanism of voltage-gated K+ channels (Kv), through fluorescence and electrical measurements. Transmembrane voltage changes are detected by the voltage sensor (helices S3b-S4) among Kv, a phenomenon which triggers a conformational change to open or close the pore. By attaching a fluorescent tag on helices S3b-S4, voltage sensor movement can be followed by fluorescence and pore opening or closure by...

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Institution:
University of Oxford
Oxford college:
Lincoln College
Department:
Mathematical,Physical & Life Sciences Division - Physics - Condensed Matter Physics
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Author

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Supervisor
Role:
Supervisor
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Funding agency for:
Lauriane Angué
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral

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