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Journal article

Ca(2+)-induced Ca2+ release in insulin-secreting cells.

Abstract:

The sulphydryl reagent thimerosal (50 microM) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells. This release was reversed after addition of the reducing agent dithiothreitol. Ca2+ was released from an Ins(1,4,5)P3-insensitive pool, since release was observed even after depletion of the Ins(1,4,5)P3-sensitive pool by a supramaximal dose of Ins(2,4,5)P3 or thapsigargin. The Ins(1,4,5)P3-sensitive pool remai...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
FEBS letters More from this journal
Volume:
296
Issue:
3
Pages:
287-291
Publication date:
1992-01-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:11725
UUID:
uuid:21c55980-779f-44a0-b8b2-96e8584bd747
Local pid:
pubs:11725
Source identifiers:
11725
Deposit date:
2012-12-19

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