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RNA interference restricts Rift Valley fever virus in multiple insect systems

Abstract:

The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in Dros...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/mSphere.00090-17

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Lorenzen, S More by this author
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Grant:
Senior Investigator Award (R.M.E.)
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Grant:
MC_UU_12014 to A.K., E.S
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Grant:
ERA-Net EMIDA (contract no. 219235) (A.K.
Publisher:
American Society for Microbiology Publisher's website
Journal:
mSphere Journal website
Volume:
2
Issue:
3
Pages:
e00090-17
Publication date:
2017-05-03
Acceptance date:
2017-03-31
DOI:
ISSN:
2379-5042
Pubs id:
pubs:719222
URN:
uri:21b9317b-fbc1-46ce-ae4f-0f0c9d2f3d94
UUID:
uuid:21b9317b-fbc1-46ce-ae4f-0f0c9d2f3d94
Local pid:
pubs:719222

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