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Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss

Abstract:

Stiff person syndrome (SPS) is a highly-disabling neurological disorder of the CNS characterized by progressive muscular rigidity and spasms. In approximately 60–80% of patients there are autoantibodies to glutamic acid decarboxylase (GAD), the enzyme that synthesizes gamma-amino butyric acid (GABA), the predominant inhibitory neurotransmitter of the CNS. Although GAD is intracellular, it is thought that autoimmunity to GAD65 may play a role in the development of SPS. To test this hypothesis,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0072921

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
8
Issue:
9
Pages:
ARTN e72921
Publication date:
2013-09-18
Acceptance date:
2013-07-15
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:21b0ee50-ff35-42cd-af01-c5e5b11cd297
Local pid:
pubs:429542
Source identifiers:
429542
Deposit date:
2013-11-16

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