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Immune enhancement of nitroreductase-induced cytotoxicity: studies using a bicistronic adenovirus vector.

Abstract:

The nitroreductase (NR)/CB1954 enzyme prodrug system has given promising results in preclinical studies and is currently being assessed in phase I clinical trials. It is well established that there is an immune component to the bystander effect observed with other systems such as thymidine kinase and cytosine deaminase; however, such an effect has not previously been described using NR. We have preliminary data suggesting an immune bystander effect with NR to further examine these effects and...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.10916

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Journal:
International journal of cancer. Journal international du cancer More from this journal
Volume:
104
Issue:
1
Pages:
104-112
Publication date:
2003-03-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136

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