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Modelling the response of vascular tumours to chemotherapy: A multiscale approach

Abstract:

An existing multiscale model is extended to study the response of a vascularised tumour to treatment with chemotherapeutic drugs which target proliferating cells. The underlying hybrid cellular automaton model couples tissue-level processes (e.g. blood flow, vascular adaptation, oxygen and drug transport) with cellular and subcellular phenomena (e.g. competition for space, progress through the cell cycle, natural cell death and drug-induced cell kill and the expression of angiogenic factors)....

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Publication status:
Published

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Publisher copy:
10.1142/S0218202506001522

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Journal:
MATHEMATICAL MODELS and METHODS IN APPLIED SCIENCES
Volume:
16
Issue:
7
Pages:
1219-1241
Publication date:
2006-07-01
DOI:
EISSN:
1793-6314
ISSN:
0218-2025
Source identifiers:
25416
Language:
English
Keywords:
Pubs id:
pubs:25416
UUID:
uuid:219d8abc-1bf5-4e0e-8dff-e08af3d00202
Local pid:
pubs:25416
Deposit date:
2012-12-19

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