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Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia

Abstract:

Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature. It also augments the activity of peripheral sympathetic nerves through activation of presynaptic angiotensin II receptors, thus contributing to sympathetic over-activity. Although some cells can synthesis angiotensin II locally, it is not known if this machinery is present in neurons closely coupled to the heart. Using a combination of RNA se...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.yjmcc.2019.11.157

Authors


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Institution:
University of Oxford
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Merton College
Role:
Author
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Name:
British Heart Foundation
Grant:
RG/17/14/33085
Publisher:
Elsevier
Journal:
Journal of Molecular and Cellular Cardiology More from this journal
Volume:
138
Pages:
234-243
Publication date:
2019-12-10
Acceptance date:
2019-11-26
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Language:
English
Keywords:
Pubs id:
pubs:1078503
UUID:
uuid:219640b0-8c6c-4286-bfbd-7be794f31564
Local pid:
pubs:1078503
Source identifiers:
1078503
Deposit date:
2019-12-20

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