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Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity

Abstract:

Iron deficiency is present in ~50% of heart failure (HF) patients. Large multicenter trials have shown that treatment of iron deficiency with i.v. iron benefits HF patients, but the underlying mechanisms are not known. To investigate the actions of iron deficiency on the heart, mice were fed an iron-depleted diet, and some received i.v. ferric carboxymaltose (FCM), an iron supplementation used clinically. Iron-deficient animals became anemic and had reduced ventricular ejection fraction measu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.125618.

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Name:
British Heart Foundation
Grant:
RG/15/9/31534
Publisher:
American Society for Clinical Investigation
Journal:
JCI Insight More from this journal
Volume:
4
Issue:
7
Article number:
e125618
Publication date:
2019-02-19
Acceptance date:
2019-02-14
DOI:
ISSN:
2379-3708
Keywords:
Pubs id:
pubs:973505
UUID:
uuid:2195007e-d6f9-4e68-8503-5b4f8a1d11c5
Local pid:
pubs:973505
Source identifiers:
973505
Deposit date:
2019-02-15

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