- Abstract:
-
To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases: type 2 diabetes (T2D), coronary artery disease (CAD) and Graves' disease. We defined, using Bayes theorem, credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal disease-associated SNPs. In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN...
Expand abstract - Publisher copy:
- 10.1038/ng.2435
-
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- Journal:
- Nature Genetics
- Volume:
- 44
- Issue:
- 12
- Pages:
- 1294-1301
- Publication date:
- 2012-12-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:2194b1c8-19cd-4c72-9783-653e43e279ef
- Source identifiers:
-
368115
- Local pid:
- pubs:368115
- Copyright date:
- 2012
Journal article
Bayesian refinement of association signals for 14 loci in 3 common diseases
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