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Bayesian refinement of association signals for 14 loci in 3 common diseases

Abstract:

To further investigate susceptibility loci identified by genome-wide association studies, we genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group and 3 diseases: type 2 diabetes (T2D), coronary artery disease (CAD) and Graves' disease. We defined, using Bayes theorem, credible sets of SNPs that were 95% likely, based on posterior probability, to contain the causal disease-associated SNPs. In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN...

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Publisher copy:
10.1038/ng.2435

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Role:
Author
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Journal:
Nature Genetics
Volume:
44
Issue:
12
Pages:
1294-1301
Publication date:
2012-12-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:2194b1c8-19cd-4c72-9783-653e43e279ef
Source identifiers:
368115
Local pid:
pubs:368115

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