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Thesis

Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN

Abstract:

Dendritic cells (DC) are one of the major antigen presenting cells (APC) of the body. They, by capture of antigen and cross-presentation of these antigens, activate dormant T-cells and co-activate B-cells. As such they regulate the immune system toward either a more humoral type immune response or a more cellular type immune response. These properties have made them very studied over the past decade and many works have focus on the development of vaccine or therapeutic using DCs as a targ...

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Institution:
University of Oxford
Research group:
Benjamin G. Davis
Oxford college:
Pembroke College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:21906fcb-b29f-415b-a1b7-bca375f06a2b
Local pid:
ora:9806

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