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Reduction of C X to CH2

Abstract:

The complete reduction of the carbonyl group of an aldehyde or ketone to a methylene/methyl group is generally achieved using the well-known Wolff-Kishner and Clemmensen reductions and these two transformations form the majority of the chapter. A range of useful procedures along with possible side reactions is presented; examples will be mainly taken from the recent literature. The use of ionic hydrogenation and metal-catalyzed hydrogenolysis, using predominantly aromatic ketones and aldehyde...

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Publisher:
Elsevier Ltd.
Volume:
8
Pages:
446-478
Host title:
Comprehensive Organic Synthesis: Second Edition
Publication date:
2014-02-05
DOI:
URN:
uuid:218d3caf-ac88-4f96-8820-f51371fe68b3
Source identifiers:
476784
Local pid:
pubs:476784
ISBN:
9780080977430

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