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Modelling overflow metabolism in Escherichia coli with flux balance analysis incorporating differential proteomic efficiencies of energy pathways

Abstract:
Background The formation of acetate by fast-growing Escherichia coli (E. coli) is a commonly observed phenomenon, often referred to as overflow metabolism. Among various studies that have been carried over decades, a recent work (Basan, M. et al. Nature 528, 99–104, 2015) suggested and validated that it is the differential proteomic efficiencies in energy biogenesis between fermentation and respiration that lead to the production of acetate at rapid growth conditions, as the ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Green Templeton College
Role:
Author
Publisher:
BioMed Central
Journal:
BMC Systems Biology More from this journal
Volume:
13
Article number:
3
Publication date:
2019-01-10
Acceptance date:
2018-12-28
DOI:
EISSN:
1752-0509
ISSN:
1752-0509
Pmid:
30630470
Language:
English
Keywords:
Pubs id:
pubs:963840
UUID:
uuid:217f66c0-7b45-4de5-bd38-479903c27858
Local pid:
pubs:963840
Source identifiers:
963840
Deposit date:
2019-03-13

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