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LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence.

Abstract:

Porphyromonas gingivalis is a Gram-negative black-pigmented obligate anaerobe implicated in the aetiology of human periodontal disease. The virulence of P. gingivalis is associated with the elaboration of the cysteine proteases Arg-gingipain (Rgp) and Lys-gingipain (Kgp), which are produced at high bacterial cell densities. To determine whether quorum sensing plays a role in the regulation of Rgp and Kgp, biosensors capable of detecting either N-acylhomoserine lactone (AHLs) or the luxS-depen...

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Publication status:
Published

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Authors


Burgess, NA More by this author
Williams, P More by this author
Hardie, KR More by this author
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Journal:
Microbiology (Reading, England)
Volume:
148
Issue:
Pt 3
Pages:
763-772
Publication date:
2002-03-05
EISSN:
1465-2080
ISSN:
1350-0872
URN:
uuid:217db317-166b-4d4b-93e8-277e6de58660
Source identifiers:
377302
Local pid:
pubs:377302

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