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ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo

Abstract:

Mammalian A-type proteins, ISCA1 and ISCA2, are evolutionarily conserved proteins involved in iron–sulfur cluster (Fe–S) biogenesis. Recently, it was shown that ISCA1 and ISCA2 form a heterocomplex that is implicated in the maturation of mitochondrial Fe4S4 proteins. Here we report that mouse ISCA1 and ISCA2 are Fe2S2-containing proteins that combine all features of Fe–S carrier proteins. We use biochemical, spectroscopic and in vivo approaches to demonstrate that despite forming a complex, I...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms15124

Authors


Beilschmidt, LK More by this author
Ollagnier de Choudens, S More by this author
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Department:
Oxford, MSD, Pathology Dunn School
Sanakis, I More by this author
Hograindleur, M-A More by this author
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Funding agency for:
Ollagnier de Choudens, S
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
15124
Pages:
1-12
Publication date:
2017-05-11
Acceptance date:
2017-03-02
DOI:
ISSN:
2041-1723
Pubs id:
pubs:698831
URN:
uri:217bc7df-7a5f-4f52-a64a-277eb12d3192
UUID:
uuid:217bc7df-7a5f-4f52-a64a-277eb12d3192
Local pid:
pubs:698831

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