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C-type natriuretic peptide and NPR-B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.

Abstract:

AIMS: B-type natriuretic peptide (BNP)-NPR-A receptor signalling inhibits cardiac sympathetic neurotransmission, although, C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesised that CNP acts similarly to BNP, and that transgenic rats (TGR) with neuron specific overexpression of a dominant negative NPR-B receptor would develop heightened sympathetic drive. METHODS AND RESULTS: Mean arterial pressure ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cvr/cvw184

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Funding agency for:
Paterson, DJ
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Funding agency for:
Herring, Neil
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Publication date:
2016-08-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pubs id:
pubs:638228
URN:
uri:2176768a-69e1-4f82-af13-ccf4630552f4
UUID:
2176768a-69e1-4f82-af13-ccf4630552f4
Local pid:
pubs:638228

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