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Journal article

C-type natriuretic peptide and NPR-B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.

Abstract:

AIMS: B-type natriuretic peptide (BNP)-NPR-A receptor signalling inhibits cardiac sympathetic neurotransmission, although, C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesised that CNP acts similarly to BNP, and that transgenic rats (TGR) with neuron specific overexpression of a dominant negative NPR-B receptor would develop heightened sympathetic drive. METHODS AND RESULTS: Mean arterial pressure ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvw184

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Funding agency for:
Buttgereit, J
Grant:
BA1374/14-1
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Funding agency for:
Paterson, D
Grant:
PG/12/87/29943
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Funding agency for:
Bader, M
Grant:
BA1374/14-1
More from this funder
Funding agency for:
Herring, N
Grant:
PG/12/87/29943
FS/15/8/3115
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Publication date:
2016-08-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Language:
English
Keywords:
Pubs id:
pubs:638228
UUID:
uuid:2176768a-69e1-4f82-af13-ccf4630552f4
Local pid:
pubs:638228
Deposit date:
2016-08-18

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