C-type natriuretic peptide and NPR-B signalling inhibits cardiac sympathetic neurotransmission and autonomic function.
AIMS: B-type natriuretic peptide (BNP)-NPR-A receptor signalling inhibits cardiac sympathetic neurotransmission, although, C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesised that CNP acts similarly to BNP, and that transgenic rats (TGR) with neuron specific overexpression of a dominant negative NPR-B receptor would develop heightened sympathetic drive. METHODS AND RESULTS: Mean arterial pressure ...Expand abstract
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- Peer reviewed
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- Buttergeit et al
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- © The Author 2016. Published on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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