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Tumour vascular disrupting agents: combating treatment resistance.

Abstract:

A large group of tubulin-binding microtubule-depolymerizing agents act as tumour vascular disrupting agents (VDAs). Several members of this group are now in clinical trials in combination with conventional anticancer drugs and radiotherapy. Here we briefly update on the development of tubulin-binding combretastatins as VDAs, summarize what is known of their mechanisms of action and address issues relating to treatment resistance, using disodium combretastatin A-4 3-O-phosphate (CA-4-P) as an ...

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Publication status:
Published

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Publisher copy:
10.1259/bjr/36205483

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
The British journal of radiology
Volume:
81 Spec No 1
Issue:
SPECIAL ISSUE
Pages:
S12-S20
Publication date:
2008-10-05
DOI:
EISSN:
1748-880X
ISSN:
0007-1285
URN:
uuid:2168bd06-f5dc-443a-865f-18863d712842
Source identifiers:
130974
Local pid:
pubs:130974

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