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A computational technique to estimate within-host productively infected cell lifetimes in emerging viral infections

Abstract:

Emerging viruses cause a lot of fatalities as they jump to humans from other species. Here we develop a novel technique to computationally estimate an important parameter of within-host viral infection: the lifespan of infected cells. Our approach is general and can be applied to a large class of viruses and leverages experimental data from replicon studies. Current techniques have difficulties reliably estimating infected cell lifetimes due to parameter identifiability and correlation of par...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7906/indecs.15.3.3

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Institution:
University of Oxford
Division:
MPLS
Role:
Author
Publisher:
Croatian Interdisciplinary Society
Journal:
Interdisciplinary Description of Complex Systems More from this journal
Volume:
15
Issue:
3
Pages:
190-198
Publication date:
2017-11-01
Acceptance date:
2017-10-18
DOI:
ISSN:
1334-4676
Keywords:
Pubs id:
pubs:742130
UUID:
uuid:216789d9-384e-46a4-a5ba-55b5d3187451
Local pid:
pubs:742130
Source identifiers:
742130
Deposit date:
2017-11-01

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