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Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.

Abstract:

UNLABELLED: Genetic lesions such as BCR-ABL1, E2A-PBX1, and MLL rearrangements (MLLr) are associated with unfavorable outcomes in adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Leukemia oncoproteins may directly or indirectly disrupt cytosine methylation patterning to mediate the malignant phenotype. We postulated that DNA methylation signatures in these aggressive B-ALLs would point toward disease mechanisms and useful biomarkers and therapeutic targets. We therefore conducted ...

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Publication status:
Published

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Journal:
Cancer discovery
Volume:
2
Issue:
11
Pages:
1004-1023
Publication date:
2012-11-05
DOI:
EISSN:
2159-8290
ISSN:
2159-8274
URN:
uuid:2160619f-a881-4d93-b1f6-fa7c91380673
Source identifiers:
358576
Local pid:
pubs:358576

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