Journal article icon

Journal article

Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.

Abstract:

Insulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.bjc.6602936

Authors


Canzian, F More by this author
Cleveland, RJ More by this author
Expand authors...
Journal:
British journal of cancer
Volume:
94
Issue:
2
Pages:
299-307
Publication date:
2006-01-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:215cd4a0-5034-4efc-8c95-55ec181aa5cb
Source identifiers:
27044
Local pid:
pubs:27044

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP