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Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial

Abstract:

Objective To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza. Design Double blind randomised trial. Setting Thirteen hospitals in Indonesia, Singapore, Thailand, and Vietnam. Participants Patients aged ≥1 year admitted to hospital with confirmed severe influenza. Interventions Oral oseltamivir at double dose (150 mg twice a day/paediatric equivalent) versus...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1136/bmj.f3039

Authors


089275/Wellcome Trust More from this funder
/Wellcome Trust More from this funder
/Medical Research Council More from this funder
089276/Wellcome Trust More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
JournalName Journal website
Volume:
346
Issue:
2
Pages:
1-16
Publication date:
2013-05-30
DOI:
EISSN:
1756-1833
ISSN:
0959-8138
Pubs id:
pubs:405838
URN:
uri:2159f8b4-d0f6-41ba-8fb3-09b719d78ada
UUID:
uuid:2159f8b4-d0f6-41ba-8fb3-09b719d78ada
Local pid:
pubs:405838

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