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Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell–mediated control of HIV-1, HCV, and HTLV-1

Abstract:

Killer cell immunoglobulin-like receptors (KIRs) are expressed predominantly on natural killer cells, where they play a key role in the regulation of innate immune responses. Recent studies show that inhibitory KIRs can also affect adaptive T cell–mediated immunity. In mice and in human T cells in vitro, inhibitory KIR ligation enhanced CD8+ T cell survival. To investigate the clinical relevance of these observations, we conducted an extensive immunogenetic analysis of multiple independent co...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1126/sciimmunol.aao2892

Authors


Silveira, M More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Oxford college:
Keble College
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Immunology Journal website
Volume:
3
Issue:
29
Pages:
Article: eaao2892
Publication date:
2018-11-09
Acceptance date:
2018-10-10
DOI:
ISSN:
2470-9468
Pubs id:
pubs:928717
URN:
uri:214e89ac-2aed-44c5-8962-8bd5caf76696
UUID:
uuid:214e89ac-2aed-44c5-8962-8bd5caf76696
Local pid:
pubs:928717

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