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Journal article

Persistent stromal fibroblast activation is present in chronic tendinopathy

Abstract:

Background

Growing evidence supports a key role for inflammation in the onset and progression of tendinopathy. However, the effects of the inflammatory infiltrate on tendon cells is poorly understood.

Methods

We investigated stromal fibroblast activation signatures in tissues and cells from patients with tendinopathy. Diseased tendons were collected from well phenotyped patient cohorts with supraspinatus tendinopathy before and after sub-acromial decompression tre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13075-016-1218-4

Authors


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Department:
Oxford, MSD, NDORMS
Buckley, CD More by this author
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Department:
Oxford, MSD, NDORMS
More by this author
Department:
Oxford, MSD, NDORMS
More by this author
Department:
Oxford, MSD, NDORMS, KIR
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Funding agency for:
Dakin, SG
National Institute for Health Research More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Arthritis Research and Therapy Journal website
Volume:
19
Pages:
16
Publication date:
2017-01-05
Acceptance date:
2016-12-29
DOI:
ISSN:
1478-6362
Pubs id:
pubs:668097
URN:
uri:2148d909-9a37-4855-9a17-723f8902d15a
UUID:
uuid:2148d909-9a37-4855-9a17-723f8902d15a
Local pid:
pubs:668097

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