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Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.

Abstract:

A significant proportion of human cancers overexpress DNA polymerase beta (Pol beta), the major DNA polymerase involved in base excision repair. The underlying mechanism and biological consequences of overexpression of this protein are unknown. We examined whether Pol beta, expressed at levels found in tumor cells, is involved in the repair of DNA damage induced by oxaliplatin treatment and whether the expression status of this protein alters the sensitivity of cells to oxaliplatin. DNA damag...

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Publication status:
Published

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Publisher copy:
10.1038/onc.2009.327

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Oncogene More from this journal
Volume:
29
Issue:
3
Pages:
463-468
Publication date:
2010-01-01
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
Language:
English
Keywords:
Pubs id:
pubs:118218
UUID:
uuid:21413757-be02-410c-b1b5-f14df00414e4
Local pid:
pubs:118218
Source identifiers:
118218
Deposit date:
2012-12-19

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