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Journal article

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations.

Abstract:

OBJECTIVES: Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. However, a substantial group of "double-negative" (MSI-/CIN-) CRCs exists. The prognosis of these patients is unclear. Furthermore, MSI and CIN are each associated with specific molecular changes, such as mutations in KRAS and...

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Publication status:
Published

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Publisher copy:
10.1038/ajg.2013.292

Authors


Mouradov, D More by this author
Domingo, E More by this author
Jorissen, RN More by this author
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Journal:
The American journal of gastroenterology
Volume:
108
Issue:
11
Pages:
1785-1793
Publication date:
2013-11-05
DOI:
EISSN:
1572-0241
ISSN:
0002-9270
URN:
uuid:213fd39f-b789-4e7e-b1cb-0e33d17b1dbd
Source identifiers:
429499
Local pid:
pubs:429499

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