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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

Abstract:

E2F1 overexpression has been shown to induce apoptosis in cooperation with p53. Using Saos-2 cells, which are null for p53 and lack functional Rb, we have demonstrated that E2F1 overexpression can also induce apoptosis in the absence of p53 and retinoblastoma protein (Rb). E2F1-induced apoptosis can be specifically inhibited by Rb but not mdm2, which is known for its ability to inhibit p53-induced apoptosis. Through the study of the apoptotic function of a set of E2F1 mutants, it was clear th...

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Publication status:
Published

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Publisher copy:
10.1101/gad.11.14.1840

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
Genes and development
Volume:
11
Issue:
14
Pages:
1840-1852
Publication date:
1997-07-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:2135af5d-4e40-47df-a33c-f489e2282e8f
Source identifiers:
84027
Local pid:
pubs:84027

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