- Abstract:
-
E2F1 overexpression has been shown to induce apoptosis in cooperation with p53. Using Saos-2 cells, which are null for p53 and lack functional Rb, we have demonstrated that E2F1 overexpression can also induce apoptosis in the absence of p53 and retinoblastoma protein (Rb). E2F1-induced apoptosis can be specifically inhibited by Rb but not mdm2, which is known for its ability to inhibit p53-induced apoptosis. Through the study of the apoptotic function of a set of E2F1 mutants, it was clear th...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1101/gad.11.14.1840
-
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- Journal:
- Genes and development
- Volume:
- 11
- Issue:
- 14
- Pages:
- 1840-1852
- Publication date:
- 1997-07-05
- DOI:
- EISSN:
-
1549-5477
- ISSN:
-
0890-9369
- URN:
-
uuid:2135af5d-4e40-47df-a33c-f489e2282e8f
- Source identifiers:
-
84027
- Local pid:
- pubs:84027
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.
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