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Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata.

Abstract:

The substantia nigra pars reticulata (SNr) plays a key role in basal ganglia function. Projections from multiple basal ganglia nuclei converge at the SNr to regulate nigrothalamic output. The SNr is also characterized by abundant aminergic input, including dopaminergic dendrites and axons containing 5-hydroxytryptamine (5-HT) or histamine (HA). The functions of HA in the SNr include motor control via HA H3 receptors (H3Rs), although the mechanism remains far from elucidated. In Parkinson's di...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
24
Issue:
40
Pages:
8704-8710
Publication date:
2004-10-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:213579a6-5af3-403c-a89b-860053655041
Source identifiers:
113358
Local pid:
pubs:113358

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