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The macrophage - a novel system to deliver gene therapy to pathological hypoxia.

Abstract:

The use of activated macrophages in the treatment of cancer has been largely ineffectual. By 'arming' these cells with the ability to express a therapeutic gene we demonstrate significant advances in the efficacy of this approach. We have used a hypoxia-regulated adenoviral vector to transduce human macrophages with either a reporter or a therapeutic gene encoding human cytochrome P4502B6 (CYP2B6). Infiltration of transduced macrophages into a tumour spheroid results in induction of gene expr...

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Publication status:
Published

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Publisher copy:
10.1038/sj.gt.3301058

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Journal:
Gene therapy More from this journal
Volume:
7
Issue:
3
Pages:
255-262
Publication date:
2000-02-01
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
Language:
English
Keywords:
Pubs id:
pubs:74050
UUID:
uuid:21305c1e-84da-410d-b2d7-ab476a55aea9
Local pid:
pubs:74050
Source identifiers:
74050
Deposit date:
2012-12-19

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