Journal article
Unique trancriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis
- Abstract:
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Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSFproducing CD4 and CD8 lymphocytes in the blood and joints of patients with spondyloarthritis, and increased numbers of IL-17A+ GM-CSF+ double-producing CD4, CD8, γδ and NK cells. GM-CSF production in CD4 T cells occurs both independently and in combination with classical Th1 and Th17 cytokines. Type 3 innate lymphoid cells ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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(pdf, 2.9MB)
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- Publisher copy:
- 10.1038/s41467-017-01771-2
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Authors
Funding
Wellcome Trust
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National Institute for Health Research
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Structural Genomics Consortium
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Pages:
- 1510
- Publication date:
- 2017-11-15
- Acceptance date:
- 2017-10-13
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Pubs id:
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pubs:736839
- URN:
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uri:21304e24-eeef-439a-8649-82a9bc594af0
- UUID:
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uuid:21304e24-eeef-439a-8649-82a9bc594af0
- Local pid:
- pubs:736839
Terms of use
- Copyright holder:
- Al-Mossawi et al.
- Copyright date:
- 2017
- Notes:
- Author(s) retain copyright; published by Nature Publishing Group. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License.
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