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Journal article

Unique trancriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

Abstract:

Spondyloarthritis encompasses a group of common inflammatory diseases thought to be driven by IL-17A-secreting type-17 lymphocytes. Here we show increased numbers of GM-CSFproducing CD4 and CD8 lymphocytes in the blood and joints of patients with spondyloarthritis, and increased numbers of IL-17A+ GM-CSF+ double-producing CD4, CD8, γδ and NK cells. GM-CSF production in CD4 T cells occurs both independently and in combination with classical Th1 and Th17 cytokines. Type 3 innate lymphoid cells ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-017-01771-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
Exeter College
Role:
Author
More by this author
Division:
Medical Sciences Division
Department:
Botnar Research Centre
Role:
Author
More by this author
Division:
Medical Sciences Division
Department:
Human Genetics Wt Centre
Role:
Author
More by this author
Division:
Medical Sciences Division
Department:
Botnar Research Centre
Role:
Author
More by this author
Division:
Medical Sciences Division
Department:
Botnar Research Centre
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Al-Mossawi, M
Grant:
Fellowship
More from this funder
Name:
Arthritis Research UK
Grant:
20773
More from this funder
Name:
Structural Genomics Consortium
More from this funder
Name:
National Institute for Health Research
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
8
Pages:
1510
Publication date:
2017-11-15
Acceptance date:
2017-10-13
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:736839
UUID:
uuid:21304e24-eeef-439a-8649-82a9bc594af0
Local pid:
pubs:736839
Source identifiers:
736839
Deposit date:
2017-10-17

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