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CD4(-)CD8alphaalpha subset of CD1d-restricted NKT cells controls T cell expansion.

Abstract:

Valpha24 invariant (Valpha24i) CD1d-restricted NKT cells are widely regarded to have immune regulatory properties. They are known to have a role in preventing autoimmune diseases and are involved in optimally mounted immune responses to pathogens and tumor cells. We were interested in understanding how these cells provide protection in autoimmune diseases. We first observed, using EBV/MHC I tetrameric complexes, that expansion of Ag-specific cells in human PBMCs was reduced when CD1d-restrict...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
172
Issue:
12
Pages:
7350-7358
Publication date:
2004-06-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:31105
UUID:
uuid:212f7b41-fc6f-4e57-8550-c52ca33e27b4
Local pid:
pubs:31105
Source identifiers:
31105
Deposit date:
2012-12-19

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