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Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction

Abstract:

We investigated the effects of leukotriene (LT) D4 and its novel potent and selective antagonist L-660,711 on isolated rat hearts with chronic myocardial infarction. The left coronary artery was ligated permanently or for 30 or 60 min and followed by reperfusion. Hearts were isolated and perfused in the Langendorff mode 4 days, 4 wk, or 8 wk after the operation. Dose-response curves for LTD4 (12-240 ng/min) on coronary flow were shifted to the left in rats with permanent coronary occlusion fo...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Gaudron, P More by this author
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Journal:
American Journal of Physiology - Heart and Circulatory Physiology
Volume:
266
Issue:
5 35-5
Publication date:
1994
ISSN:
0363-6135
URN:
uuid:212acc88-8b92-4236-95fc-4547fbefdb4d
Source identifiers:
441466
Local pid:
pubs:441466

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