Journal article icon

Journal article

Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours.

Abstract:

The Min mouse is a model for human familial adenomatous polyposis (FAP), an autosomal dominant disease characterised by multiple adenomatous gastrointestinal polyps. The severity of the Min phenotype is modified by a locus (Mom1) on mouse chromosome 4, at a position syntenic with human chromosome 1p35-p36. The secretory phospholipase A2 (Pla2s) gene is a candidate for this modifier locus and there is evidence that a locus on human chromosome 1p35-p36 acts to modify the severity of human duode...

Expand abstract

Actions


Access Document


Authors


Journal:
Annals of human genetics
Volume:
60
Issue:
Pt 5
Pages:
369-376
Publication date:
1996-09-05
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
URN:
uuid:21292d83-63a3-487d-b144-f9ad8e162456
Source identifiers:
72309
Local pid:
pubs:72309

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP