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Dynamic alteration in splenic function during acute falciparum malaria.

Abstract:

Plasmodium-infected erythrocytes lose their normal deformability and become susceptible to splenic filtration. In animal models, this is one mechanism of antimalarial defense. To assess the effect of acute falciparum malaria on splenic filtration, we measured the clearance of heated 51Cr-labeled autologous erythrocytes in 25 patients with acute falciparum malaria and in 10 uninfected controls. Two groups of patients could be distinguished. Sixteen patients had splenomegaly, markedly accelerat...

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Publication status:
Published

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Publisher copy:
10.1056/nejm198709103171105

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
New England journal of medicine More from this journal
Volume:
317
Issue:
11
Pages:
675-679
Publication date:
1987-09-01
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Language:
English
Keywords:
Pubs id:
pubs:42858
UUID:
uuid:2117988f-ea6b-4326-84aa-47603e440936
Local pid:
pubs:42858
Source identifiers:
42858
Deposit date:
2012-12-19

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