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The cohesin ring uses its hinge to organize DNA using non-topological as well as topological mechanisms

Abstract:

As predicted by the notion that sister chromatid cohesion is mediated by entrapment of sister DNAs inside cohesin rings, there is perfect correlation between co-entrapment of circular minichromosomes and sister chromatid cohesion. In most cells where cohesin loads without conferring cohesion, it does so by entrapment of individual DNAs. However, cohesin with a hinge domain whose positively charged lumen is neutralized loads and moves along chromatin despite failing to entrap DNAs. Thus, cohes...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.cell.2018.04.015

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
St Hilda's College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
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Funding agency for:
Nasmyth, KA
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Funding agency for:
Nasmyth, KA
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Funding agency for:
Nasmyth, KA
Publisher:
Elsevier Publisher's website
Journal:
Cell Journal website
Volume:
173
Issue:
6
Pages:
1508-1519.e18
Publication date:
2018-05-10
Acceptance date:
2018-04-10
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pubs id:
pubs:847197
URN:
uri:21118648-f6df-45d3-ae26-3392ec1f5067
UUID:
uuid:21118648-f6df-45d3-ae26-3392ec1f5067
Local pid:
pubs:847197

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