Parental transmission of MS in a population-based Canadian cohort.

Journal article

OBJECTIVE: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. The precise nature of these factors and mode of inheritance remains unknown. A female predominance is universally found. Recently, offspring of affected fathers were reported to be more likely to have MS than those of affected mothers. This was attributed to the Carter effect, which is seen in polygenic disorders. The Carter effect predicts that affected parents of the sex lesser affe...

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Authors: Herrera, B; Ramagopalan, S; Orton, S; Chao, M; Yee, I

• Publication status: Published
• Journal: Neurology
• Volume: 69
• Issue: 12
• Pages: 1208-1212
• Publication date: 2007-09-01
• DOI: 10.1212/01.wnl.0000268486.40851.d6
• EISSN: 1526-632X
• ISSN: 0028-3878
• Language: English
• Keywords: Longitudinal Studies; Cohort Studies; Humans; Risk Factors; Genetic Predisposition to Disease; Inheritance Patterns; Male; Pedigree; Genetic Load; Canada; Multifactorial Inheritance; Female; Multiple Sclerosis; Sex Characteristics