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Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2.

Abstract:

BACKGROUND and AIMS: The vagus nerve negatively regulates macrophage cytokine production via the release of acetylcholine (ACh) and activation of nicotinic acetylcholine receptors (nAChR). In various models of intestinal inflammation, vagus nerve efferent stimulation ameliorates disease. Given the actively constrained cytokine responses of intestinal macrophages, we explored the effect of nAChR activation on endocytosis and phagocytosis by macrophages residing in the peritoneal and mucosal c...

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Publication status:
Published

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Journal:
Gastroenterology
Volume:
137
Issue:
3
Pages:
1029-1039.e4
Publication date:
2009-09-01
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
Source identifiers:
28442
Language:
English
Keywords:
Pubs id:
pubs:28442
UUID:
uuid:21019e6f-1562-43f3-9df8-d2a290685fea
Local pid:
pubs:28442
Deposit date:
2012-12-19

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