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Thesis

Characterising the determinants of hypoxia inducible transcription factors binding to chromatin

Abstract:

Hypoxia regulates many hundreds of genes that play important roles in numerous physiological and pathophysiological processes. The hypoxia inducible transcription factors (HIFs) are central to the transcriptional activation of these hypoxia-regulated genes. However, to date, little is known about the determinants of HIF-1 and HIF-2 binding site selection. Both HIF-1 and HIF-2 appear to bind as HIF-α/HIF-1β heterodimers, and recognise the same core consensus DNA motif, the hypoxia response ...

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James Smythies More by this author

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Department:
Nuffield Department of Medicine
Role:
Supervisor
Department:
Nuffield Department of Medicine
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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