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DNA charge neutralization by linear polymers: Irreversible binding

Abstract:

We develop a deterministic mathematical model to describe the way in which polymers bind to DNA by considering the dynamics of the gap distribution that forms when polymers bind to a DNA plasmid. In so doing, we generalize existing theory to account for overlaps and binding cooperativity whereby the polymer binding rate depends on the size of the overlap. The proposed mean-field models are then solved using a combination of numerical and asymptotic methods. We find that overlaps lead to highe...

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Publisher copy:
10.1103/PhysRevE.74.011904

Authors


Journal:
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume:
74
Issue:
1
Publication date:
2006-01-01
DOI:
EISSN:
1550-2376
ISSN:
1539-3755
URN:
uuid:20ead296-ae58-4246-9cfb-6211c5f84389
Source identifiers:
319121
Local pid:
pubs:319121
Language:
English

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