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Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection.

Abstract:

Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). Her...

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Publication status:
Published

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Authors


Bäckdahl, L More by this author
Francis, RS More by this author
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Journal:
Science translational medicine
Volume:
3
Issue:
83
Pages:
83ra40
Publication date:
2011-05-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:20e37b28-ddf4-4ff5-9e80-de58252c4db0
Source identifiers:
141623
Local pid:
pubs:141623

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