- Abstract:
-
CONTEXT: Blood homocysteine levels are positively associated with cardiovascular disease, but it is uncertain whether the association is causal. OBJECTIVE: To assess the effects of reducing homocysteine levels with folic acid and vitamin B(12) on vascular and nonvascular outcomes. DESIGN, SETTING, AND PATIENTS: Double-blind randomized controlled trial of 12,064 survivors of myocardial infarction in secondary care hospitals in the United Kingdom between 1998 and 2008. INTERVENTIONS: 2 mg folic...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1001/jama.2010.840
-
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- Journal:
- JAMA
- Volume:
- 303
- Issue:
- 24
- Pages:
- 2486-2494
- Publication date:
- 2010-06-05
- DOI:
- EISSN:
-
1538-3598
- ISSN:
-
0098-7484
- URN:
-
uuid:20e1353f-0bee-49a9-a5ed-f359180fd430
- Source identifiers:
-
60712
- Local pid:
- pubs:60712
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.
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