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Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an A.T-rich 14-mer duplex.

Abstract:

The NMR solution structure of the A.T rich DNA 14-mer duplex d(ATACATGGTACATA).d(TATGTACCATGTAT) is reported. This is compared with the NMR structure of the same duplex intrastrand cross-linked at the d(G*pG*) site by cis-(Pt(NH3)2¿2+, derived from the anticancer drug cisplatin. The unmodified duplex has B-DNA geometry, but there is a large positive base-pair roll (roll angle 24 +/- 2 degrees) at the T9-A10 step on the 3' side of the central GG site. Platination of the DNA duplex causes the a...

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Publication status:
Published

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Authors


Parkinson, JA More by this author
del Socorro Murdoch, P More by this author
Berners-Price, SJ More by this author
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Journal:
Chemistry (Weinheim an der Bergstrasse, Germany)
Volume:
6
Issue:
19
Pages:
3636-3644
Publication date:
2000-10-05
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
URN:
uuid:20e07881-4333-400f-b34a-423106f18005
Source identifiers:
400068
Local pid:
pubs:400068

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