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Changes in the hemagglutinin of H5N1 viruses during human infection - Influence on receptor binding

Abstract:

As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans of current H5N1 viruses only requires a few genetic changes. An essential step is alteration of the virus hemagglutinin from preferential binding to avian receptors for the recognition of human receptors present in the upper airway. We have identified receptor-binding changes which emerged d...

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Publisher copy:
10.1016/j.virol.2013.08.010

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Journal:
Virology
Volume:
447
Issue:
1-2
Pages:
326-337
Publication date:
2013-12-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:20dcffe1-2e94-4cd6-8d06-ced0ed604e08
Source identifiers:
439081
Local pid:
pubs:439081

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