Journal article
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
- Alternative title:
- Recurrent activating ACVR1/ALK2 mutations in diffuse intrinsic pontine glioma
- Abstract:
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Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 1.9MB, Terms of use)
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- Publisher copy:
- 10.1038/ng.2925
Authors
Funding
+ Takeda Pharmaceutical Company Limited
More from this funder
Funding agency for:
Bullock, A
Grant:
092809/Z/10/Z
+ Novartis Research Foundation
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Funding agency for:
Bullock, A
Grant:
092809/Z/10/Z
+ Ontario Ministry of Economic Development and Innovation
More from this funder
Funding agency for:
Bullock, A
Grant:
092809/Z/10/Z
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Genetics More from this journal
- Volume:
- 46
- Pages:
- 457-461
- Publication date:
- 2014-01-01
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
Item Description
- Language:
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English
- Subjects:
- UUID:
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uuid:20c32fdc-5a01-4765-ab24-9731bc1834b2
- Local pid:
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ora:8389
- Deposit date:
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2014-05-08
Terms of use
- Copyright holder:
- Nature Publishing Group
- Copyright date:
- 2014
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