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Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in ankylosing spondylitis.

Abstract:

OBJECTIVES: To evaluate the efficacy and safety of an oral phosphodiesterase 4 inhibitor, apremilast, in treatment of ankylosing spondylitis (AS) by monitoring symptoms and signs in a pilot study including exploratory investigation of effects of PDE4 inhibition on blood biomarkers of bone biology. METHODS: In this double-blind, placebo-controlled, single-centre, Phase II study, patients with symptomatic AS with active disease on MRI were randomised to apremilast 30 mg BID or placebo over 12 ...

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Authors


Abraham, S More by this author
Van Rossen, E More by this author
Withrington, R More by this author
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Journal:
Annals of the rheumatic diseases
Volume:
72
Issue:
9
Pages:
1475-1480
Publication date:
2013-09-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:209c3d39-d3fc-4fd8-b7ab-8ce1852b764b
Source identifiers:
352521
Local pid:
pubs:352521

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