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Journal article

The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila.

Abstract:

Inappropriate regulation of the PI3-kinase/PTEN/Akt kinase-signalling cassette, a key downstream target of insulin/insulin-like growth factor signalling (IIS), is associated with several major human diseases such as diabetes, obesity and cancer. In Drosophila, studies have recently revealed that different subcellular pools of activated, phosphorylated Akt can modulate different IIS-dependent processes. For example, a specific pool of activated Akt within the cytoplasm alters aspects of lipid ...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.035220

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Journal of cell science
Volume:
121
Issue:
Pt 20
Pages:
3383-3392
Publication date:
2008-10-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:209b4470-040e-4281-b9d6-ac758a6e4a46
Source identifiers:
113909
Local pid:
pubs:113909

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