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Adjuvant whole-brain radiation therapy compared with observation after local treatment of melanoma brain metastases: a multicenter, randomized phase III trial

Abstract:

Purpose The brain is a common site of metastasis for patients with high-risk melanoma. Although surgery or stereotactic radiosurgery are highly effective local treatments for a small number of metastases, there is a high risk of developing additional brain metastases. The role of adjuvant whole-brain radiotherapy (WBRT) in reducing new metastases is controversial, with a lack of high-level evidence specifically for melanoma.

Methods In this randomiz...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0003-0167-1685
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Grant:
PdCCRS Grants 512358, 1009485, 1084046
Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Volume:
37
Issue:
33
Pages:
3132-3141
Publication date:
2019-09-25
Acceptance date:
2019-08-07
DOI:
ISSN:
1527-7755
Pubs id:
pubs:1039841
UUID:
uuid:2099f136-5939-45ab-8bbf-4ca44579dc67
Source identifiers:
1039841
Local pid:
pubs:1039841
Language:
English
Keywords:

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