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Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

Abstract:

The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. ...

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Publication status:
Published

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Publisher copy:
10.1038/nchembio.1093

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Journal:
Nature chemical biology
Volume:
8
Issue:
12
Pages:
960-962
Publication date:
2012-12-05
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
URN:
uuid:20947b6a-1e4e-4bb5-951b-4d57edee4d70
Source identifiers:
368114
Local pid:
pubs:368114

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