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A randomised phase II trial and feasibility study of palliative chemotherapy in frail or elderly patients with advanced gastroesophageal cancer (321GO)

Abstract:

BACKGROUND: Elderly patients are commonly under-represented in cancer clinical trials. The 321GO was undertaken in preparation for a definitive phase three trial assessing different chemotherapy regimens in a frail and/or elderly population with advanced gastroesophageal (GO) cancer. METHODS: Patients with advanced GO cancer considered unfit for conventional dose chemotherapy were randomly assigned in a 1 : 1 : 1 ratio to: epirubicin, oxaliplatin and capecitabine (EOX); oxaliplatin and capeci...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/bjc.2016.442

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Department:
Oxford, MSD, Oncology
Role:
Author
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Grant:
Feasibility Study Project CRUK/08/033
Publisher:
Cancer Research UK Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
116
Issue:
4
Pages:
472-478
Publication date:
2017-01-17
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Pubs id:
pubs:671862
URN:
uri:20701c52-a940-4c72-9a94-633ba8e00e27
UUID:
uuid:20701c52-a940-4c72-9a94-633ba8e00e27
Local pid:
pubs:671862
Paper number:
4

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