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Defective DNA repair and neurodegenerative disease.

Abstract:

Defects in cellular DNA repair processes have been linked to genome instability, heritable cancers, and premature aging syndromes. Yet defects in some repair processes manifest themselves primarily in neuronal tissues. This review focuses on studies defining the molecular defects associated with several human neurological disorders, particularly ataxia with oculomotor apraxia 1 (AOA1) and spinocerebellar ataxia with axonal neuropathy 1 (SCAN1). A picture is emerging to suggest that brain cell...

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Publisher copy:
10.1016/j.cell.2007.08.043

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cell
Volume:
130
Issue:
6
Pages:
991-1004
Publication date:
2007-09-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
376198

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