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Effect of blocking TNF on IL-6 levels and metastasis in a B16-BL6 melanoma/mouse model.

Abstract:

We studied the relationship between tumour necrosis factor (TNF) and interleukin 6 (IL-6) levels, and the metastatic process in C57BL/6 mice after intravenous inoculation of B16-BL6 melanoma cells. Bioactive TNF was not detectable in the sera of inoculated mice, but these animals did show higher TNF levels following intraperitoneal challenge with lipopolysaccharide (LPS) compared to control animals. Serum IL-6 levels were increased in inoculated animals. Injection of a hybrid molecule (p55-sf...

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Publication status:
Published

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Authors


Cubillos, S More by this author
Scallon, B More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Anticancer research
Volume:
17
Issue:
3C
Pages:
2207-2211
Publication date:
1997
EISSN:
1791-7530
ISSN:
0250-7005
URN:
uuid:2067d0f8-7139-43be-9c83-21410d8dcaa5
Source identifiers:
481926
Local pid:
pubs:481926

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